Ketoconazole – Oral

Understanding Ketoconazole: An Antifungal Medication for Your Pets

Ketoconazole, known by its brand name Nizoral®, is a powerful antifungal medication that effectively treats fungal infections in pets. However, its benefits don’t stop there. This medication has also been utilized to reduce the dosage of expensive drugs like cyclosporine by influencing their metabolism. Let’s dive deeper into the world of ketoconazole and discover its many uses.

How is Ketoconazole Administered?

Ketoconazole is available in the form of tablets and oral liquid. It should be given orally with food, preferably high-fat foods such as cheese, butter, or cream cheese. You can also opt for a compounded oral liquid. Remember to follow the instructions on the label and measure the doses carefully. Although this medication may take a few weeks to show full effects, gradual improvements can typically be observed within a few days.

Missed Dose? Here’s What to Do

If you accidentally miss a dose, administer it as soon as you remember. However, if it’s close to the time for the next dose, it’s best to skip the missed dose and continue with the regular dosing schedule. Never double the dose or provide extra doses to your pet.

Potential Side Effects and Risk Factors

As with any medication, there are potential side effects to be aware of. The most common side effects of ketoconazole include lack of appetite, vomiting, diarrhea, and weight loss. In rare cases, liver toxicity may occur, resulting in severe vomiting, loss of appetite, and yellowing of the skin and gums. Additionally, changes in bloodwork, such as suppression of cortisol and testosterone levels, may be observed. While long-term use of this medication may be associated with cataract formation, it usually ceases to be effective after a few days. However, in pets with liver or kidney disease, the effects may persist for a longer duration.

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Ketoconazole should not be used in pets that are allergic to it. In cats, due to its toxic side effects and the availability of safer alternatives, it is generally not recommended. Caution should be exercised when using ketoconazole in pets with liver disease, low platelet counts, or those undergoing stressful events like serious illness, surgery, or trauma. For pregnant pets, ketoconazole should only be used if it is essential to treat a life-threatening infection. It can cause temporary infertility in breeding pets and should be used cautiously in nursing pets as it is excreted in milk.

Drug Interactions: What You Need to Know

When administering ketoconazole, it’s crucial to be aware of potential drug interactions. Exercise caution when giving this medication in combination with antacids, antiarrhythmics, tricyclic antidepressants, benzodiazepines, and many other medications. It’s essential to inform your veterinarian about all medications, including vitamins, supplements, and herbal therapies, that your pet is taking.

Monitoring and Storage Guidelines

Regular monitoring is necessary to ensure the safe and effective use of ketoconazole. A complete blood count, focusing on platelets, should be conducted during treatment. For long-term use, liver enzymes should be monitored every 2-3 months in the first six months and twice yearly thereafter. Pay close attention to any potential side effects, particularly signs of low cortisol levels. Your veterinarian may also want to monitor your pet to assess the medication’s effectiveness. Ketoconazole should be stored at room temperature in a dry place protected from moisture.

In Case of Emergency

If you suspect an overdose or observe any adverse reactions to the medication, contact your veterinary office immediately. If they are unavailable, follow their instructions for reaching an emergency facility.

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Ketoconazole, with its antifungal properties and additional benefits, is a valuable medication for treating fungal infections in pets. Always consult with your veterinarian and carefully follow their directions for optimal results. Your pet’s health and well-being are always a priority.

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