High Levels of Protein in Dog Urine: Understanding Proteinuria in Dogs


If you’ve noticed that your furry friend’s urine contains an unusually high level of protein, it could be a sign of proteinuria. While it’s normal for dogs to have some protein in their urine, excessive amounts can indicate an underlying health condition. In this article, we’ll explore the causes, symptoms, diagnosis, and treatment options for proteinuria in dogs.

What Is Proteinuria?

Proteinuria refers to the presence of excess protein in a dog’s urine. While kidney disease is the most common cause of proteinuria, it can also be triggered by infections, inflammation, urinary tract issues, tumors, and high blood pressure. Proteinuria itself is not a disease but rather an indication that something is amiss and requires attention.

Symptoms of Proteinuria in Dogs

In many cases, dogs with proteinuria may not display any noticeable symptoms. It’s often discovered during a routine urinalysis at the veterinarian’s office. However, severe cases of proteinuria, especially those caused by kidney disease, may present symptoms such as lethargy, increased thirst, swelling in the legs or abdomen, difficulty breathing, and blood clots.

Common Causes of Proteinuria in Dogs

Proteinuria can be caused by various factors affecting the urinary tract, including kidney disease. Some common causes include hemolysis (rupture of blood cells), rhabdomyolysis (muscle breakdown), infections, cancers, inflammation (e.g., pancreatitis), kidney issues (injury, failure, chronic kidney disease), high blood pressure, hormonal imbalances (e.g., Cushing’s disease, diabetes mellitus), genetic predisposition, amyloidosis, and unknown causes (idiopathic).

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Dog Breeds Prone to Proteinuria

Certain dog breeds are more susceptible to proteinuria than others. These breeds include the Bernese Mountain Dog, Doberman Pinscher, Bull Terrier, English Cocker Spaniel, Samoyed, Miniature Schnauzer, Chinese Shar-Pei, Soft Coated Wheaten Terrier, English Foxhound, Belgian Malinois, Bullmastiff, and Norwegian Elkhound.

Diagnosis and Treatment

To diagnose proteinuria, your veterinarian will conduct a urinalysis to measure protein levels in your dog’s urine. If high levels of protein are found, further testing, such as a urine protein to creatinine ratio (UPCR) test, may be recommended. Additional tests will help identify the underlying cause and determine appropriate treatment options.

Treatment for proteinuria focuses on addressing the underlying condition causing it. For kidney disease, treatment may involve regular monitoring, medications to alleviate symptoms and reduce pressure on the kidneys, and specialized diets. Infections causing proteinuria are typically treated with antibiotics, while high blood pressure may require medications to manage it. In cases of specific cancers like multiple myeloma, targeted treatments are necessary.

Recovery and Management

Resolving proteinuria requires treating the underlying cause. Early detection is crucial for developing an effective treatment plan. While some causes can be easily treated, chronic conditions like inflammatory bowel disease, Cushing’s disease, or diabetes mellitus may require long-term management. Unfortunately, in severe cases of inherited kidney disorders, kidney cancer, or kidney failure, stabilizing the disease may be challenging or only achievable for a limited period.


Proteinuria in dogs is not a condition in itself but rather a symptom of an underlying health issue. Regular check-ups, prompt veterinary care, and adhering to the recommended treatment plan can help manage proteinuria and improve your dog’s quality of life. If you notice any abnormal signs or suspect proteinuria, consult your veterinarian for a proper diagnosis and guidance.

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For more information about proteinuria in dogs, visit Katten TrimSalon.